发布时间 : 星期三 文章090210生物工程下游技术更新完毕开始阅读5ff5caa92bf90242a8956bec0975f46526d3a7d1
Building industry opens up new world of entrepreneurial struggle to build a three provinces of regional central cities--in the Communist x counties the six plenary session members and comrades: today, I was commissioned by the County party Committee Standing Committee, reports to the General Assembly. Consideration of all members and alternates, and comrades attending advice. A, and this year yilai of work recalled this year yilai, in municipal of right led Xia, County solidarity led County people, to science development views for guide, to good activities for mainline, according to \nizations three more\opment thought, concentrated poly force, work hard, political, and economic, and culture, and social and party of construction are made has new progress, County rendering out wind fresh are, and career prosperity, and social settled, and people mind into of good situation. (A) facilitating the construction of the project. Firmly establish the \oject ieconomic, grasping development project is to hold\osophy, to extraordinary efforts to promoting the construction of key projects. Plot 108 key projects for the year, with a total investment of 29.3 billion yuan, iron plate, Josh stone cement waste heat power generation and 13 projects completed, worship of 1.2 million tons of pellets, Hua Yu 80,000 sets of grandparent chicken farming, 47 projects under construction, completed investment of 3.95 billion yuan, annual plan of 69.3%. The first half of the County's gross domestic product is expectd to reached 8.5 billion yuan, and total revenue of 943 million Yuan. (B) structural adjustment achieved remarkable results. Actively transforming the pattern of economic development, industrial ecology, and agricultural modernization and industrialization of services. High x-County • Tin iron circular economy demonstration area, and further expand economic development zone Jing Dian recycle economy ecology industry Park, Park, circular economy and rapid economic development. Focus more on the dialectical relationship between development and environmental protection, energy saving and emission reduction projects play an important role. Vigorously developing agriculture, ecological agriculture, agriculture, modern agricultural clearing along the River Promenade begins to take shape. Key tourism projects is going well, WA Palace area was named \n most influential cultural relics in Hebei province landscape\op new services, and services with new developments. (C) urban-rural integration process. Promoting \difference\battle of two large demolition completed 32 days of 530,000 square meters, exceeded the annual ask 7 months in advance. General big building jiangjun road, bridge and highway bridges, the green heart of the city and other urban construction projects, and focus on building new countryside and new housing model villages, urban and rural areas improve. Highway opened to traffic, Liu Zhang, Qing LAN high-speed x-County section completed by the end of August. Urban and rural《生物工程下游技术》课程（）教学大纲
一、课程基本信息
课程中文名称：生物工程下游技术 课程代码：
学分与学时：72学时，4学分 课程性质：专业必修
授课对象：生物技术及应用专业
二、课程教学目标与任务
《生物分离工程》是为生物工程本科专业学生开设的一门专业必修课，是培养学生今后从事生物技术产业领域应该具备的思考、分析和解决问题能力的主干课程。通过本课程的学习：
1、使学生掌握生物产品的提取、分离、纯化、精制加工等技术的科学本质、原理、方法、规律。
2、使学生了解生物工程下游技术的科学前沿及其发展趋势。
3、培养学生应用所学理论知识、分析和解决生产及科研中的实际问题的基本能力。 三、学时安排
课程内容与学时分配表 章节 第一章 第二章 第三章 第四章 第五章 第六章 第七章 第八章 第九章 第十章 绪论 下游技术的理论基础 发酵液的预处理 微生物细胞的破碎 沉淀 萃取 膜分离过程 吸附和离子交换 色谱技术 结晶技术 内容 学时 4 4 4 4 4 16 8 6 8 4 4 4 2 第十一章 蒸发 第十二章 干燥 第十三章 清洁生产导论
四、课程教学内容与基本要求
第一章 绪论（4学时）
教学目的：了解生物工业下游技术的发展历史。
基本要求：对生物工程下游分离技术的流程和发展趋势大致了解
evelopment work steadily in the pilot counties, to build peace neighborhood offices approved, %urban and rural communities (Center), immigrant communities, pilot projects such as integrated management of urban and rural sanitation in order. (D) maintain social harmony and stability. In the case of tight financial situation, continue to increase the input of people, happy people battle. Urban central heating and upgrade rural power grids, rural reconstruction of shabby housing ten major projects being delivered, has been overfulfilled ahead. Strengthening of social programs, college entrance examination to record heights; new rural insurance coverage rate of the city's first, launched in new rural cooperative medical clinic co-ordination; ... Perfect Park catering, accommodation, education, recreation and other tertiary industries supporting, improving socialization service level, for industries, businesses and create a good environment for development. 3, flexible investment, enhance the industry. Construction of industrial parks, just set up a platform for the development of only attract more projects into the district, to form agglomeration advantages. A innovation project. To be purposeful, targeted investment, will have a basis of the County's industrial packaged bundles, overall publicity and promotion. Initiative going, please come in and carry out all-round, multi-level and wide-range of investment activities. The Township industrial projects, in principle, to put to the West industrial parks. What town project, is that the output value of the Township. Second, we must grasp the standards selected items. Full account of extend the industry chain and the integration of factors of production, not only efforts to introduce a number of scientific and technological content and high added value, growth and strong driving force of large projects and large enterprises, but also on domestic-funded enterprises and in accordance with the direction of industrial development of small and medium projects, project man, small project overwhelming. Meet the area of the County's new industrial projects and city back into rural enterprises, in principle, all stationed in industrial parks. Meanwhile, strict control of excess capacity and high energy consumption, high emission enterprises to enter. Thirdly, increased incentives on the project. Investment of the whole society, the Township and County units go out and draft project. To establish investment incentives for successful introduction of significant project gives awards to units and individuals, the introduction of tax for the implementation of the project, to introduce organization into rewards. 4, preferential policies, and security industries. In terms of project examination and approval, by area Administrative Committee in conjunction with the development, planning, land, industry and commerce, quality control and other departments, \-stop reception, one-stop service\procedures, the time limit originally. In the management of EIA in accordance with theBuilding industry opens up new world of entrepreneurial struggle to build a three provinces of regional central cities--in the Communist x counties the six plenary session members and comrades: today, I was commissioned by the County party Committee Standing Committee, reports to the General Assembly. Consideration of all members and alternates, and comrades attending advice. A, and this year yilai of work recalled this year yilai, in municipal of right led Xia, County solidarity led County people, to science development views for guide, to good activities for mainline, according to \nizations three more\opment thought, concentrated poly force, work hard, political, and economic, and culture, and social and party of construction are made has new progress, County rendering out wind fresh are, and career prosperity, and social settled, and people mind into of good situation. (A) facilitating the construction of the project. Firmly establish the \oject ieconomic, grasping development project is to hold\osophy, to extraordinary efforts to promoting the construction of key projects. Plot 108 key projects for the year, with a total investment of 29.3 billion yuan, iron plate, Josh stone cement waste heat power generation and 13 projects completed, worship of 1.2 million tons of pellets, Hua Yu 80,000 sets of grandparent chicken farming, 47 projects under construction, completed investment of 3.95 billion yuan, annual plan of 69.3%. The first half of the County's gross domestic product is expected to reached 8.5 billion yuan, and total revenue of 943 million Yuan. (B) structural adjustment achieved remarkable results. Actively transforming the pattern of economic development, industrial ecology, and agricultural modernization and industrialization of services. High x-County • Tin iron circular economy demonstration area, and further expand economic development zone Jing Dian recycle economy ecology industry Park, Park, circular economy and rapid economic development. Focus more on the dialectical relationship between development and environmental protection, energy saving and emission reduction projects play an important role. Vigorously developing agriculture, ecological agriculture, agriculture, modern agricultural clearing along the River Promenade begins to take shape. Key tourism projects is going well, WA Palace area was named \n most influential cultural relics in Hebei province landscape\op new services, and services with new developments. (C) urban-rural integration process. Promoting \difference\battle of two large demolition completed 32 days of 530,000 square meters, exceeded the annual ask 7 months in advance. General big building jiangjun road, bridge and highway bridges, the green heart of the city and other urban construction projects, and focus on building new countryside and new housing model villages, urban and rural areas improve. Highway opened to traffic, Liu Zhang, Qing LAN high-speed x-County section completed by the end of August. Urban and rural重点与难点： 下游技术的一般工艺过程 教学方法： 多媒体教学 主要内容：
1、生物工程下游技术的工作领域 2、生物工业下游技术的一般工艺过程 3、生物工业下游技术的发展动态
第二章 下游技术的理论基础（4学时）
教学目的： 使学生了解下游技术的理论基础，为学习具体有技术奠定基础
基本要求：了解下游技术的基本理论基础，了解下游技术常见的分离手段，掌握分离效率的评价标准。
重点与难点：分离机理、分离效价的评价标准 教学方法：多媒体讲授 主要内容： 1、分离机理 2、分离操作
3、分离效价的评价
第三章 发酵液的预处理（4学时）
教学目的： 学习并掌握发酵液预处理的一般方法
基本要求：掌握发酵液的过滤特性，掌握改善发酵过滤特性的方法，掌握高价无机离子与杂蛋白质去除的方法，掌握常见的固液分离技术（离心、过滤）的原理
重点与难点： 改善发酵液过滤特性的方法，无机离子的去除方法，澄清过滤和滤饼过滤的差别。
教学方法： 多媒体课件教学与课堂讨论相结合 主要内容：
1、发酵液过滤特性的改变 2、发酵液的相对纯化 3、固液分离工程及设备
第四章 微生物细胞的破碎（4学时）
教学目的： 学习并掌握细胞破碎的基本方法
基本要求：掌握细胞破碎的阻力来源于细胞壁，掌握常用的细胞破碎的方法及原理，了解包含体的概念及其分离、复性。掌握细胞破碎的发展方向。
重点与难点： 机械破壁的原理、化学法破碎细胞的方法及原理 教学方法：多媒体讲授与实例讲解相结合 主要内容：
1、细胞破碎的阻力
2、细胞破碎及产物释放原理 3、包含体的分离及蛋白质的复性 4、破碎技术的研究方向
第五章 溶剂萃取和浸取（4学时）
教学目的： 学习溶剂萃取的原理及操作方式
evelopment work steadily in the pilot counties, to build peace neighborhood offices approved, %urban and rural communities (Center), immigrant communities, pilot projects such as integrated management of urban and rural sanitation in order. (D) maintain social harmony and stability. In the case of tight financial situation, continue to increase the input of people, happy people battle. Urban central heating and upgrade rural power grids, rural reconstruction of shabby housing ten major projects being delivered, has been overfulfilled ahead. Strengthening of social programs, college entrance examination to record heights; new rural insurance coverage rate of the city's first, launched in new rural cooperative medical clinic co-ordination; ... Perfect Park catering, accommodation, education, recreation and other tertiary industries supporting, improving socialization service level, for industries, businesses and create a good environment for development. 3, flexible investment, enhance the industry. Construction of industrial parks, just set up a platform for the development of only attract more projects into the district, to form agglomeration advantages. A innovation project. To be purposeful, targeted investment, will have a basis of the County's industrial packaged bundles, overall publicity and promotion. Initiative going, please come in and carry out all-round, multi-level and wide-range of investment activities. The Township industrial projects, in principle, to put to the West industrial parks. What town project, is that the output value of the Township. Second, we must grasp the standards selected items. Full account of extend the industry chain and the integration of factors of production, not only efforts to introduce a number of scientific and technological content and high added value, growth and strong driving force of large projects and large enterprises, but also on domestic-funded enterprises and in accordance with the direction of industrial development of small and medium projects, project man, small project overwhelming. Meet the area of the County's new industrial projects and city back into rural enterprises, in principle, all stationed in industrial parks. Meanwhile, strict control of excess capacity and high energy consumption, high emission enterprises to enter. Thirdly, increased incentives on the project. Investment of the whole society, the Township and County units go out and draft project. To establish investment incentives for successful introduction of significant project gives awards to units and individuals, the introduction of tax for the implementation of the project, to introduce organization into rewards. 4, preferential policies, and security industries. In terms of project examination and approval, by area Administrative Committee in conjunction with the development, planning, land, industry and commerce, quality control and other departments, \-stop reception, one-stop service\procedures, the time limit originally. In the management of EIA in accordance with theBuilding industry opens up new world of entrepreneurial struggle to build a three provinces of regional central cities--in the Communist x counties the six plenary session members and comrades: today, I was commissioned by the County party Committee Standing Committee, reports to the General Assembly. Consideration of all members and alternates, and comrades attending advice. A, and this year yilai of work recalled this year yilai, in municipal of right led Xia, County solidarity led County people, to science development views for guide, to good activities for mainline, according to \nizations three more\opment thought, concentrated poly force, work hard, political, and economic, and culture, and social and party of construction are made has new progress, County rendering out wind fresh are, and career prosperity, and social settled, and people mind into of good situation. (A) facilitating the construction of the project. Firmly establish the \oject ieconomic, grasping development project is to hold\osophy, to extraordinary efforts to promoting the construction of key projects. Plot 108 key projects for the year, with a total investment of 29.3 billion yuan, iron plate, Josh stone cement waste heat power generation and 13 projects completed, worship of 1.2 million tons of pellets, Hua Yu 80,000 sets of grandparent chicken farming, 47 projects under construction, completed investment of 3.95 billion yuan, annual plan of 69.3%. The first half of the County's gross domestic product is expected to reached 8.5 billion yuan, and total revenue of 943 million Yuan. (B) structural adjustment achieved remarkable results. Actively transforming the pattern of economic development, industrial ecology, and agricultural modernization and industrialization of services. High x-County • Tin iron circular economy demonstration area, and further expand economic development zone Jing Dian recycle economy ecology industry Park, Park, circular economy and rapid economic development. Focus more on the dialectical relationship between development and environmental protection, energy saving and emission reduction projects play an important role. Vigorously developing agriculture, ecological agriculture, agriculture, modern agricultural clearing along the River Promenade begins to take shape. Key tourism projects is going well, WA Palace area was named \n most influential cultural relics in Hebei province landscape\op new services, and services with new developments. (C) urban-rural integration process. Promoting \difference\battle of two large demolition completed 32 days of 530,000 square meters, exceeded the annual ask 7 months in advance. General big building jiangjun road, bridge and highway bridges, the green heart of the city and other urban construction projects, and focus on building new countryside and new housing model villages, urban and rural areas improve. Highway opened to traffic, Liu Zhang, Qing LAN high-speed x-County section completed by the end of August. Urban and rural基本要求：掌握溶剂萃取的原理，掌握影响萃取的因素，掌握乳化现象及破乳化的方法，了解工业用萃取的设备，掌握萃取的操作流程，掌握浸取的概念。
重点与难点： 影响萃取的因素、乳化、萃取的操作流程 教学方法： 多媒体课件教学、实例教学 主要内容：
1、萃取的基本概念 2、分配定律和分配平衡 3、有机溶剂萃取 4、浸取
第六章 超临界流体萃取（4学时）
教学目的：掌握超临界流体萃取的基本原理
基本要求：掌握超临界流体及超临界流体萃取的概念，掌握萃取的基本原理，了解萃取的基本流程和应用领域。
重点与难点：超临界流体萃取的基本原理 教学方法： 多媒体课件教学 主要内容：
1、什么是超临界流体 2、什么是超临界流体萃取 3、超临界流体萃取的基本原理
第七章 双水相萃取（4学时）
教学目的：掌握双水相萃取的基本原理和操作方式
基本要求：掌握双水相系统形成的原理，掌握双水相相图，影响双水相萃取的因素。简单了解双水相萃取的应用。
重点与难点：双水相系统相图
教学方法：多媒体课件教学、课堂实验辅助 主要内容： 1、双水相系统
2、双水相的分配平衡，影响分配平衡的因素 3、双水相系统的应用
第八章 反胶团萃取（4学时）
教学目的：学习反胶团萃取的基本原理
基本要求：掌握反胶团的形成因素及其功能、掌握反胶团制备的方法，掌握反胶团萃取的基本原理，清楚影响反胶团萃取的因素。 了解反胶团萃取的应用。
重点与难点：反胶团与胶团形成的过程，反胶团萃取的基本原理 教学方法：多媒体教学 主要内容：
1、什么是反胶团，反胶团的两个特异性功能 2、反胶团的制备方法 3、反胶团萃取的基本原理 4、影响反胶团萃取的主要因素 5、反胶团萃取的应用
evelopment work steadily in the pilot counties, to build peace neighborhood offices approved, %urban and rural communities (Center), immigrant communities, pilot projects such as integrated management of urban and rural sanitation in order. (D) maintain social harmony and stability. In the case of tight financial situation, continue to increase the input of people, happy people battle. Urban central heating and upgrade rural power grids, rural reconstruction of shabby housing ten major projects being delivered, has been overfulfilled ahead. Strengthening of social programs, college entrance examination to record heights; new rural insurance coverage rate of the city's first, launched in new rural cooperative medical clinic co-ordination; ... Perfect Park catering, accommodation, education, recreation and other tertiary industries supporting, improving socialization service level, for industries, businesses and create a good environment for development. 3, flexible investment, enhance the industry. Construction of industrial parks, just set up a platform for the development of only attract more projects into the district, to form agglomeration advantages. A innovation project. To be purposeful, targeted investment, will have a basis of the County's industrial packaged bundles, overall publicity and promotion. Initiative going, please come in and carry out all-round, multi-level and wide-range of investment activities. The Township industrial projects, in principle, to put to the West industrial parks. What town project, is that the output value of the Township. Second, we must grasp the standards selected items. Full account of extend the industry chain and the integration of factors of production, not only efforts to introduce a number of scientific and technological content and high added value, growth and strong driving force of large projects and large enterprises, but also on domestic-funded enterprises and in accordance with the direction of industrial development of small and medium projects, project man, small project overwhelming. Meet the area of the County's new industrial projects and city back into rural enterprises, in principle, all stationed in industrial parks. Meanwhile, strict control of excess capacity and high energy consumption, high emission enterprises to enter. Thirdly, increased incentives on the project. Investment of the whole society, the Township and County units go out and draft project. To establish investment incentives for successful introduction of significant project gives awards to units and individuals, the introduction of tax for the implementation of the project, to introduce organization into rewards. 4, preferential policies, and security industries. In terms of project examination and approval, by area Administrative Committee in conjunction with the development, planning, land, industry and commerce, quality control and other departments, \-stop reception, one-stop service\procedures, the time limit originally. In the management of EIA in accordance with theBuilding industry opens up new world of entrepreneurial struggle to build a three provinces of regional central cities--in the Communist x counties the six plenary session members and comrades: today, I was commissioned by the County party Committee Standing Committee, reports to the General Assembly. Consideration of all members and alternates, and comrades attending advice. A, and this year yilai of work recalled this year yilai, in municipal of right led Xia, County solidarity led County people, to science development views for guide, to good activities for mainline, according to \nizations three more\opment thought, concentrated poly force, work hard, political, and economic, and culture, and social and party of construction are made has new progress, County rendering out wind fresh are, and career prosperity, and social settled, and people mind into of good situation. (A) facilitating the construction of the project. Firmly establish the \oject ieconomic, grasping development project is to hold\osophy, to extraordinary efforts to promoting the construction of key projects. Plot 108 key projects for the year, with a total investment of 29.3 billion yuan, iron plate, Josh stone cement waste heat power generation and 13 projects completed, worship of 1.2 million tons of pellets, Hua Yu 80,000 sets of grandparent chicken farming, 47 projects under construction, completed investment of 3.95 billion yuan, annual plan of 69.3%. The first half of the County's gross domestic product is expected to reached 8.5 billion yuan, and total revenue of 943 million Yuan. (B) structural adjustment achieved remarkable results. Actively transforming the pattern of economic development, industrial ecology, and agricultural modernization and industrialization of services. High x-County • Tin iron circular economy demonstration area, and further expand economic development zone Jing Dian recycle economy ecology industry Park, Park, circular economy and rapid economic development. Focus more on the dialectical relationship between development and environmental protection, energy saving and emission reduction projects play an important role. Vigorously developing agriculture, ecological agriculture, agriculture, modern agricultural clearing along the River Promenade begins to take shape. Key tourism projects is going well, WA Palace area was named \n most influential cultural relics in Hebei province landscape\op new services, and services with new developments. (C) urban-rural integration process. Promoting \difference\battle of two large demolition completed 32 days of 530,000 square meters, exceeded the annual ask 7 months in advance. General big building jiangjun road, bridge and highway bridges, the green heart of the city and other urban construction projects, and focus on building new countryside and new housing model villages, urban and rural areas improve. Highway opened to traffic, Liu Zhang, Qing LAN high-speed x-County section completed by the end of August. Urban and rural
第九章 膜分离过程（8学时）
教学目的：掌握膜分离的基本理论及膜分离过程
基本要求：了解膜分离的发展历史，掌握膜分离的分类依据、主要类型及常见类型的分离机理，了解膜的制造材料，掌握膜的结构特点，掌握膜组件的类型，了解其特点，掌握膜的操作特性。基本掌握影响膜分离的因素，基本掌握膜的污染及清洗，基本掌握膜的使用寿命。简单了解膜的应用。
重点与难点： 常见膜分离的类型及其分离机理，膜的操作特性。 教学方法： 多媒体课件教学 主要内容：
1、膜和膜分离过程的分类与特征
2、膜的基本理论：分离机理、性能、参数 3、膜组件
4、膜的操作特性
5、影响膜分离速度的因素 6、膜的污染与清洗 7、膜的使用寿命 8、膜分离的应用
第十章 液膜分离（4学时）
教学目的：掌握液膜的基本理论及分离过程
基本要求：掌握液膜的基本理论及乳化液膜的制备，分离机制和分离过程。 重点与难点： 乳化液膜的制备、分离机制 教学方法：多媒体教学 主要内容：
1、液膜的分类和组成
2、乳化液膜的制备和分离机制
3、乳化液膜分离技术的工艺流程及其应用 4、关于膜过程不利因素的讨论
第十一章 离子交换法（8学时）
教学目的：学习离子交换树脂交换的基本原理。
基本要求：掌握离子交换树脂的种类及理化性能，掌握离子交换法的基本原理，基本掌握影响离子交换的因素，了解离子交换法的应用。
重点与难点：离子交换的基本原理、离子交换法的操作过程 教学方法：多媒体课件教学、结合工厂实际 主要内容：
1、离子交换树脂及分类
2、离子交换树脂的性能与测定 3、离子交换过程的理论基础： （1）离子交换平衡
evelopment work steadily in the pilot counties, to build peace neighborhood offices approved, %urban and rural communities (Center), immigrant communities, pilot projects such as integrated management of urban and rural sanitation in order. (D) maintain social harmony and stability. In the case of tight financial situation, continue to increase the input of people, happy people battle. Urban central heating and upgrade rural power grids, rural reconstruction of shabby housing ten major projects being delivered, has been overfulfilled ahead. Strengthening of social programs, college entrance examination to record heights; new rural insurance coverage rate of the city's first, launched in new rural cooperative medical clinic co-ordination; ... Perfect Park catering, accommodation, education, recreation and other tertiary industries supporting, improving socialization service level, for industries, businesses and create a good environment for development. 3, flexible investment, enhance the industry. Construction of industrial parks, just set up a platform for the development of only attract more projects into the district, to form agglomeration advantages. A innovation project. To be purposeful, targeted investment, will have a basis of the County's industrial packaged bundles, overall publicity and promotion. Initiative going, please come in and carry out all-round, multi-level and wide-range of investment activities. The Township industrial projects, in principle, to put to the West industrial parks. What town project, is that the output value of the Township. Second, we must grasp the standards selected items. Full account of extend the industry chain and the integration of factors of production, not only efforts to introduce a number of scientific and technological content and high added value, growth and strong driving force of large projects and large enterprises, but also on domestic-funded enterprises and in accordance with the direction of industrial development of small and medium projects, project man, small project overwhelming. Meet the area of the County's new industrial projects and city back into rural enterprises, in principle, all stationed in industrial parks. Meanwhile, strict control of excess capacity and high energy consumption, high emission enterprises to enter. Thirdly, increased incentives on the project. Investment of the whole society, the Township and County units go out and draft project. To establish investment incentives for successful introduction of significant project gives awards to units and individuals, the introduction of tax for the implementation of the project, to introduce organization into rewards. 4, preferential policies, and security industries. In terms of project examination and approval, by area Administrative Committee in conjunction with the development, planning, land, industry and commerce, quality control and other departments, \-stop reception, one-stop service\procedures, the time limit originally. In the management of EIA in accordance with the